Characterising the optimal pulse number and frequency for inducing analgesic effects with motor cortex rTMS

High- (?5Hz), but not low-frequency (?1Hz) rTMS (repetitive Transcranial Magnetic Stimulation) of the contralateral primary motor cortex (M1) can induce transient analgesic effects [5]. However, impact TMS frequency and pulse number remains poorly understood may present an opportunity to optimise efficacy promote long-term effects. Prior work indicated that a single session consisting 2,000, 500 pulses 10Hz rTMS, was necessary significant alleviation neuropathic pain relative sham stimulation [7].